Warren J B, McCusker M, Fuller R W
Department of Clinical Pharmacology, Hammersmith Hospital, London, U.K.
Clin Allergy. 1988 Mar;18(2):197-9. doi: 10.1111/j.1365-2222.1988.tb02859.x.
Six atopic subjects received either adrenaline (0.3 ml of 1 mg/ml), subcutaneously over the deltoid muscle, or saline on 2 separate days. After 10 min, histamine and antigen were injected intradermally in the forearm. Adrenaline significantly inhibited the flare of histamine and both the flare and weal of antigen (P less than 0.05). This anti-allergic action of adrenaline occurred with a dose that we have previously shown produces plasma concentrations at the upper limit of the physiological range in resting normal subjects.
六名特应性受试者在两个不同的日子里，分别于三角肌皮下注射肾上腺素（0.3毫升1毫克/毫升）或生理盐水。10分钟后，在前臂皮内注射组胺和抗原。肾上腺素显著抑制了组胺引起的风团以及抗原引起的风团和红晕（P<0.05）。肾上腺素的这种抗过敏作用发生时的剂量，是我们之前表明在静息正常受试者中能产生生理范围上限血浆浓度的剂量。
