Warren J B, Newman C M, Pixley F J, Fuller R W, Dollery C T
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
Br J Clin Pharmacol. 1988 Dec;26(6):803-5. doi: 10.1111/j.1365-2125.1988.tb05324.x.
On three separate occasions 12 atopic subjects were injected intradermally with two doses of antigen and one of saline as control. Pretreatment with terfenadine 60 mg orally significantly inhibited the flare response to both the lower dose of antigen and to saline (P less than 0.05). Ingestion of enalapril 5 mg orally 3 h before increased the flare response to both doses of antigen. Neither enalapril nor terfenadine affected the weal response when compared with placebo. Both endogenous histamine and bradykinin appear to be released during the intradermal flare response but are not important in the weal reaction to antigen.
在三个不同的场合，对12名特应性受试者进行皮内注射，分别给予两剂抗原和一剂生理盐水作为对照。口服60毫克特非那定进行预处理，可显著抑制对较低剂量抗原和生理盐水的风团反应（P<0.05）。在注射前3小时口服5毫克依那普利，会增强对两剂抗原的风团反应。与安慰剂相比，依那普利和特非那定都不影响风团反应。内源性组胺和缓激肽似乎在皮内风团反应过程中释放，但在对抗原的风团反应中并不重要。
