Department of Food Chemistry and Nutrition, Jagiellonian University, Krakow, Poland.
Department of Gynecological Endocrinology, Medical College Jagiellonian University, Krakow, Poland.
J Trace Elem Med Biol. 2017 Dec;44:241-246. doi: 10.1016/j.jtemb.2017.08.012. Epub 2017 Aug 24.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. To date, no systematic study of interactions between selenium status parameters (SSPs: serum selenium concentration, plasma glutathione peroxidase, GPX3, plasma selenoprotein P, SELENOP), sex hormones, thyroid function parameters, and other laboratory parameters in patients with PCOS has been undertaken. Therefore we aimed to compare such parameters in women with PCOS and in the control groups, and to investigate the multidimensional interactions between various parameters in PCOS patients and in controls. The subjects were diagnosed either with PCOS (n=28, 25.4±5.2 y) or with PCOS+Hashimoto disease (n=13, 27.3±5.6 y). Female patients having normal menses were recruited into the first control group (n=70, 26.8±7.3 y) or to the second control group comprising women only with Hashimoto disease (n=10, 26.2±6.9 y). No apparent differences in SSPs between control subjects and patients with PCOS, also complicated with Hashimoto disease, were identified, though such differences were noticeable for total testosterone (tT), sex hormone binding globulin, free androgen index, dehydroepiandrosterone sulfate (DHEAS), and insulin profile. The correlation between tT and DHEAS was found the strongest. The other group of mutually highly and positively correlated parameters consisted of GPX3, follicle stimulating hormone, free triiodothyronine and free thyroxine. All the latter parameters correlated negatively with vitamin D3. SSPs took part in interactions with thyroid hormones, sex hormones and some other parameters, but only for GPX3 such interactions were statistically significant. The significance of these findings remains open for further investigation, particularly in patients with PCOS and/or Hashimoto disease.
多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌疾病。迄今为止，尚未对 PCOS 患者的硒状态参数（SSP：血清硒浓度、血浆谷胱甘肽过氧化物酶、GPX3、血浆硒蛋白 P、SELENOP）、性激素、甲状腺功能参数与其他实验室参数之间的相互作用进行系统研究。因此，我们旨在比较 PCOS 患者和对照组之间的这些参数，并研究 PCOS 患者和对照组之间各种参数之间的多维相互作用。研究对象被诊断为 PCOS（n=28，25.4±5.2 岁）或 PCOS+桥本甲状腺炎（n=13，27.3±5.6 岁）。月经正常的女性患者被纳入第一对照组（n=70，26.8±7.3 岁）或仅包括桥本甲状腺炎女性的第二对照组（n=10，26.2±6.9 岁）。对照组和同时患有桥本甲状腺炎的 PCOS 患者之间的 SSP 没有明显差异，尽管总睾酮（tT）、性激素结合球蛋白、游离雄激素指数、脱氢表雄酮硫酸盐（DHEAS）和胰岛素谱存在差异。tT 和 DHEAS 之间的相关性最强。另一组相互高度正相关的参数包括 GPX3、卵泡刺激素、游离三碘甲状腺原氨酸和游离甲状腺素。所有这些参数均与维生素 D3 呈负相关。SSP 参与与甲状腺激素、性激素和其他一些参数的相互作用，但只有 GPX3 的相互作用具有统计学意义。这些发现的意义有待进一步研究，特别是在 PCOS 和/或桥本甲状腺炎患者中。
