Karami Mohammed, Almaghrabi Safa, Banasr Omar, Hussein Khulood
Department of Clinical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Emergency, King Abdullah Medical Hospital, Jeddah, Saudi Arabia.
Biol Trace Elem Res. 2024 Nov 6. doi: 10.1007/s12011-024-04435-7.
Growing evidence indicates a potential link between polycystic ovary syndrome (PCOS) and selenium (Se) levels. This study aims to assess Se concentrations in Saudi women with and without PCOS and to explore the relationships between Se levels, insulin resistance (IR), adiponectin, and lipid markers. We randomly recruited 197 women aged 18 to 40, both with and without PCOS, for this age-matched case-control study. The PCOS participants were categorized into three groups based on their Se levels. All participants underwent interviews, and their anthropometric measurements and blood samples were collected for further analysis of biochemical variables. There was a notable difference between the two groups studied across all biochemical variables. Specifically, fasting blood glucose, insulin, the homeostasis model assessment (HOMA-IR) index, total cholesterol, low-density lipoprotein cholesterol, and triglycerides were significantly higher in the PCOS group compared to the control group (p < 0.01). Conversely, Se, high-density lipoprotein cholesterol, and adiponectin levels were significantly lower in women with PCOS than in their age-matched controls (p < 0.01). HOMA-IR was identified as the sole independent predictor of serum Se levels, explaining 17.2% of the variability in its circulating levels (β = - 0.57; 95% CI: - 0.96 to - 0.18, p = 0.004). The findings reveal that women with PCOS have lower serum Se levels compared to the controls. Furthermore, the results confirm a correlation between Se levels and insulin resistance.
越来越多的证据表明多囊卵巢综合征（PCOS）与硒（Se）水平之间存在潜在联系。本研究旨在评估患有和未患有PCOS的沙特女性的硒浓度，并探讨硒水平、胰岛素抵抗（IR）、脂联素和脂质标志物之间的关系。我们随机招募了197名年龄在18至40岁之间、患有和未患有PCOS的女性，进行这项年龄匹配的病例对照研究。PCOS参与者根据其硒水平分为三组。所有参与者都接受了访谈，并收集了他们的人体测量数据和血液样本，以进一步分析生化变量。在所有生化变量方面，所研究的两组之间存在显著差异。具体而言，与对照组相比，PCOS组的空腹血糖、胰岛素、稳态模型评估（HOMA-IR）指数、总胆固醇、低密度脂蛋白胆固醇和甘油三酯显著更高（p < 0.01）。相反，患有PCOS的女性的硒、高密度脂蛋白胆固醇和脂联素水平显著低于其年龄匹配的对照组（p < 0.01）。HOMA-IR被确定为血清硒水平的唯一独立预测因子，解释了其循环水平变异性的17.2%（β = -0.57；95% CI：-0.96至-0.18，p = 0.004）。研究结果表明，与对照组相比，患有PCOS的女性血清硒水平较低。此外，结果证实了硒水平与胰岛素抵抗之间的相关性。
