Wang Yao-Chien, Yang Kai-Wei, Lee Tien-Ying Peter, Lin Cheng-Li, Liaw Geng-Wang, Hung Dong-Zong, Kao Chia-Hung, Chen Wei-Kung, Yang Tse-Yen
Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
YeeZen General Hospital, Taoyuan, Taiwan.
Alcohol. 2017 Nov;64:23-28. doi: 10.1016/j.alcohol.2017.05.003. Epub 2017 Aug 18.
We designed a population-based retrospective cohort study to investigate the association between the event of alcohol intoxication and the risk of pyogenic liver abscess. The present study enrolled 245,076 patients with a history of alcohol intoxication from 2000 to 2010 and matched each of them with four comparison patients, with similar mean age and sex ratios. We determined the cumulative incidences and adjusted hazard ratios (aHRs) of liver abscess. A significant association was observed between alcohol intoxication and liver abscess. The incidence density rate of liver abscess was 3.47-fold greater in the alcohol intoxication (AI) cohort than in the non-AI cohort (12.2 vs. 3.43 per 10,000 person-years), with an adjusted HR (aHR) of 2.64 (95% CI = 2.26 to 3.08). This population-based study positively associated the event of alcohol intoxication with increased risk of liver abscess. Our findings warrant further large-scale and in-depth investigations in this area.
我们设计了一项基于人群的回顾性队列研究，以调查酒精中毒事件与化脓性肝脓肿风险之间的关联。本研究纳入了2000年至2010年间有酒精中毒史的245,076名患者，并将他们每人与四名对照患者进行匹配，这些对照患者的平均年龄和性别比例相似。我们确定了肝脓肿的累积发病率和调整后的风险比（aHRs）。观察到酒精中毒与肝脓肿之间存在显著关联。酒精中毒（AI）队列中肝脓肿的发病密度率比非AI队列高3.47倍（每10,000人年分别为12.2和3.43），调整后的风险比（aHR）为2.64（95%置信区间=2.26至3.08）。这项基于人群的研究表明酒精中毒事件与肝脓肿风险增加呈正相关。我们的研究结果值得在该领域进行进一步的大规模深入调查。
