血小板衍生生长因子-C 和 -D 在心血管系统和疾病中的作用。
Platelet-derived growth factor-C and -D in the cardiovascular system and diseases.
机构信息
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, PR China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, PR China.
出版信息
Mol Aspects Med. 2018 Aug;62:12-21. doi: 10.1016/j.mam.2017.09.005. Epub 2017 Oct 13.
The cardiovascular system is among the first organs formed during development and is pivotal for the formation and function of the rest of the organs and tissues. Therefore, the function and homeostasis of the cardiovascular system are finely regulated by many important molecules. Extensive studies have shown that platelet-derived growth factors (PDGFs) and their receptors are critical regulators of the cardiovascular system. Even though PDGF-C and PDGF-D are relatively new members of the PDGF family, their critical roles in the cardiovascular system as angiogenic and survival factors have been amply demonstrated. Understanding the functions of PDGF-C and PDGF-D and the signaling pathways involved may provide novel insights into both basic biomedical research and new therapeutic possibilities for the treatment of cardiovascular diseases.
心血管系统是发育过程中最早形成的器官之一，对其他器官和组织的形成和功能至关重要。因此，心血管系统的功能和稳态受到许多重要分子的精细调节。大量研究表明，血小板衍生生长因子（PDGFs）及其受体是心血管系统的关键调节剂。尽管 PDGF-C 和 PDGF-D 是 PDGF 家族的相对较新成员，但它们作为血管生成和存活因子在心血管系统中的关键作用已得到充分证明。了解 PDGF-C 和 PDGF-D 的功能及其涉及的信号通路可能为基础生物医学研究和心血管疾病治疗的新治疗可能性提供新的见解。
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