血小板衍生生长因子-C 和 D 在血管疾病及动物模型中的信号作用。
PDGF-C and PDGF-D signaling in vascular diseases and animal models.
机构信息
Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Division of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
出版信息
Mol Aspects Med. 2018 Aug;62:1-11. doi: 10.1016/j.mam.2018.01.005. Epub 2018 Feb 14.
Members of the platelet-derived growth factor (PDGF) family are well known to be involved in different pathological conditions. The cellular and molecular mechanisms induced by the PDGF signaling have been well studied. Nevertheless, there is much more to discover about their functions and some important questions to be answered. This review summarizes the known roles of two of the PDGFs, PDGF-C and PDGF-D, in vascular diseases. There are clear implications for these growth factors in several vascular diseases, such as atherosclerosis and stroke. The PDGF receptors are broadly expressed in the cardiovascular system in cells such as fibroblasts, smooth muscle cells and pericytes. Altered expression of the receptors and the ligands have been found in various cardiovascular diseases and current studies have shown important implications of PDGF-C and PDGF-D signaling in fibrosis, neovascularization, atherosclerosis and restenosis.
血小板衍生生长因子（PDGF）家族成员被广泛认为与多种病理状态有关。PDGF 信号诱导的细胞和分子机制已得到充分研究。然而，它们的功能还有很多有待发现，一些重要的问题需要解答。本文综述了 PDGF-C 和 PDGF-D 这两种 PDGF 在血管疾病中的已知作用。这些生长因子在多种血管疾病中具有明确的意义，如动脉粥样硬化和中风。PDGF 受体在心血管系统中广泛表达于成纤维细胞、平滑肌细胞和周细胞等细胞中。在各种心血管疾病中发现了受体和配体的表达改变，目前的研究表明 PDGF-C 和 PDGF-D 信号在纤维化、新生血管形成、动脉粥样硬化和再狭窄中的重要意义。
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