Toda N
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.
Eur J Pharmacol. 1988 Mar 1;147(2):291-3. doi: 10.1016/0014-2999(88)90790-x.
Diltiazem induced a concentration-dependent relaxation of monkey coronary arterial strips which were partially contracted with clonidine, phenylephrine, norepinephrine, prostaglandin F2 alpha. This relaxation occurred to a similar extent, but was significantly less than that observed in arteries contracted with K+. Contractions mediated via alpha 2-adrenoceptors do not appear to be more susceptible to diltiazem than those caused by activation of alpha 1-adrenoceptors and prostaglandin F2 alpha receptors.
地尔硫䓬使可乐定、去氧肾上腺素、去甲肾上腺素、前列腺素F2α预收缩的猴冠状动脉条产生浓度依赖性舒张。这种舒张程度相似，但明显小于钾离子预收缩动脉时所观察到的舒张程度。通过α2肾上腺素能受体介导的收缩似乎并不比由α1肾上腺素能受体和前列腺素F2α受体激活所引起的收缩更易受地尔硫䓬影响。
