Watanabe Yusuke, Sakakura Kenichi, Akashi Naoyuki, Ishikawa Mami, Taniguchi Yousuke, Yamamoto Kei, Wada Hiroshi, Fujita Hideo, Momomura Shin-Ichi
Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Department of Neurosurgery, Saitama Medical Center, Jichi Medical University.
Int Heart J. 2017 Oct 21;58(5):831-834. doi: 10.1536/ihj.16-483. Epub 2017 Sep 30.
While most of pulmonary thromboembolism (PE) cases can be managed by thrombolytic and anticoagulation therapy, massive PE remains a life-threatening disease. Although surgical embolectomy can be a curative therapy for massive PE, peri-operative mortality for hemodynamically collapsed PE is extremely high. We present a case of hemodynamically collapsed massive PE. We avoided either thrombolytic therapy or surgical embolectomy, because the patient had recent cerebral contusion. Therefore, we managed the patient with the combination of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and conventional anticoagulation, which dramatically improved the patient's hemodynamics. In conclusion, the combination of V-A ECMO and conventional anticoagulation may be the preferred first line therapy for the patients with cardiogenic shock following massive PE.
虽然大多数肺血栓栓塞症(PE)病例可通过溶栓和抗凝治疗进行管理,但大面积PE仍然是一种危及生命的疾病。尽管手术取栓术可作为大面积PE的治愈性疗法,但血流动力学衰竭的PE患者围手术期死亡率极高。我们报告一例血流动力学衰竭的大面积PE病例。由于该患者近期有脑挫伤,我们避免了溶栓治疗或手术取栓术。因此,我们采用静脉-动脉体外膜肺氧合(V-A ECMO)与传统抗凝相结合的方法对患者进行治疗,这显著改善了患者的血流动力学。总之,V-A ECMO与传统抗凝相结合可能是大面积PE后心源性休克患者的首选一线治疗方法。