Department of Respiratory Medicine, Hangzhou Fuyang First People's Hospital, Hangzhou, Zhejiang, China (mainland).
Med Sci Monit. 2017 Oct 2;23:4715-4722. doi: 10.12659/msm.904087.
BACKGROUND The objective of the present study was to investigate whether the analysis of magnesium (Mg), high-sensitivity C-reactive protein (hsCRP), and ischemia-modified albumin (IMA) concentrations can be used as a non-invasive and convenient method for diagnosing obstructive sleep apnea syndrome (OSAS). MATERIAL AND METHODS After polysomnography, venous blood was collected from 33 patients with OSAS and 30 control individuals. Serum levels of Mg, hsCRP, and IMA were investigated. The relationship between these factors and apnea-hypopnea index (AHI) was analyzed using the Pearson correlation coefficient. The role of the factors was determined using a receiver operating characteristic (ROC) curve and multivariate logistic regression analysis. RESULTS The levels of hsCRP and IMA were significantly higher in patients with OSAS than in control subjects, while the levels of Mg were lower (P<0.05 for all). A significant correlation was noted between serum IMA (r=0.614; P<0.001) and hsCRP (r=0.453; P<0.001) levels and the AHI. The ROC showed that serum Mg (AUC=0.74(0.62-0.85)), hsCRP (AUC=0.77(0.65-0.87)), and IMA (AUC=0.78(0.66-0.87)) levels could be used as markers to diagnose OSAS. Moreover, our new model, MIh, which is obtained by multivariate analysis, yielded an AUC value of 0.93 (0.83-0.98). Continuous positive airway pressure (CPAP) treatment reversed the changes in the serum levels of Mg, hsCRP, and IMA. CONCLUSIONS Patients with OSAS show reduced serum Mg levels and elevated serum hsCRP and IMA levels. These observed alterations can be reversed by CPAP treatment. A novel model, named MIh, may be a promising tool for OSAS diagnosis.
本研究旨在探讨分析镁（Mg）、高敏 C 反应蛋白（hsCRP）和缺血修饰白蛋白（IMA）浓度是否可作为诊断阻塞性睡眠呼吸暂停综合征（OSAS）的一种非侵入性和便捷的方法。
经多导睡眠图检查后，采集 33 例 OSAS 患者和 30 例对照个体的静脉血。检测血清中 Mg、hsCRP 和 IMA 水平。采用 Pearson 相关系数分析这些因素与呼吸暂停低通气指数（AHI）的关系。采用受试者工作特征（ROC）曲线和多因素 logistic 回归分析确定这些因素的作用。
OSAS 患者的 hsCRP 和 IMA 水平明显高于对照组，而 Mg 水平较低（均 P<0.05）。血清 IMA（r=0.614；P<0.001）和 hsCRP（r=0.453；P<0.001）水平与 AHI 呈显著相关。ROC 显示血清 Mg（AUC=0.74(0.62-0.85)）、hsCRP（AUC=0.77(0.65-0.87)）和 IMA（AUC=0.78(0.66-0.87)）水平可作为诊断 OSAS 的标志物。此外，通过多因素分析得到的新模型 MIh 的 AUC 值为 0.93（0.83-0.98）。持续气道正压通气（CPAP）治疗可逆转血清 Mg、hsCRP 和 IMA 水平的变化。
OSAS 患者血清 Mg 水平降低，hsCRP 和 IMA 水平升高。CPAP 治疗可逆转这些改变。一种名为 MIh 的新模型可能是 OSAS 诊断的有前途的工具。
