Guangxi Medical University Graduate School, Guangxi, China.
Clinics (Sao Paulo). 2013 Jul;68(7):968-73. doi: 10.6061/clinics/2013(07)13.
To investigate the effect of obstructive sleep apnea and continuous positive airway pressure treatment on serum butyrylcholinesterase activity and ischemia-modified albumin levels.
Thirty-two patients with obstructive sleep apnea and 30 age- and sex-matched controls were enrolled and underwent a diagnostic polysomnogram. The serum butyrylcholinesterase activity, ischemia-modified albumin levels, metabolic parameters, and polysomnography scores were detected and evaluated. Nine patients were studied before and after treatment with continuous positive airway pressure.
The serum ischemia-modified albumin levels were significantly higher and the butyrylcholinesterase activity was significantly lower in patients with obstructive sleep apnea than in the controls (p<0.001). The continuous positive airway pressure treatment decreased the modified albumin levels and elevated the buthrylcholinesterase activity (p=0.019 and p=0.023, respectively). The modified albumin levels were positively correlated with the apnea-hypopnea index (r=0.462, p=0.008) at baseline. Elevated ischemia-modified albumin levels can be more accurate than butyrylcholinesterase activity at reflecting the presence of obstructive sleep apnea. Receiver operating characteristic curves revealed a significant difference between the areas under the curve 0.916 for ischemia-modified albumin and 0.777 for butyrylcholinesterase (z=2.154, p=0.031).
The elevated ischemia-modified albumin level was significantly associated with obstructive sleep apnea and was more sensitive than butyrylcholinesterase activity in reflecting obstructive sleep apnea. The continuous positive airway pressure treatment helped to ameliorate the imbalance.
探讨阻塞性睡眠呼吸暂停及持续气道正压通气治疗对血清丁酰胆碱酯酶活性和缺血修饰白蛋白水平的影响。
纳入 32 例阻塞性睡眠呼吸暂停患者和 30 例年龄、性别匹配的对照者，行诊断性多导睡眠图检查。检测并评估血清丁酰胆碱酯酶活性、缺血修饰白蛋白水平、代谢参数和多导睡眠图评分。9 例患者在持续气道正压通气治疗前后进行了研究。
阻塞性睡眠呼吸暂停患者的血清缺血修饰白蛋白水平显著升高，丁酰胆碱酯酶活性显著降低（均 p<0.001）。持续气道正压通气治疗降低了改良白蛋白水平，提高了丁酰胆碱酯酶活性（p=0.019 和 p=0.023）。改良白蛋白水平与基线时的呼吸暂停-低通气指数呈正相关（r=0.462，p=0.008）。升高的缺血修饰白蛋白水平在反映阻塞性睡眠呼吸暂停方面可能比丁酰胆碱酯酶活性更准确。受试者工作特征曲线显示，缺血修饰白蛋白的曲线下面积显著大于丁酰胆碱酯酶（0.916 对 0.777，z=2.154，p=0.031）。
升高的缺血修饰白蛋白水平与阻塞性睡眠呼吸暂停显著相关，在反映阻塞性睡眠呼吸暂停方面比丁酰胆碱酯酶活性更敏感。持续气道正压通气治疗有助于改善这种失衡。
