Dhakal Bishnu, Gamage Lalith S R, Zhang Yanshi, Herndon James W
Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003 USA.
Tetrahedron Lett. 2017 Apr 5;58(14):1403-1407. doi: 10.1016/j.tetlet.2017.02.070. Epub 2017 Feb 24.
Three-component coupling of Fischer carbene complexes, enyne aldehyde hydrazones, and electron-deficient alkynes leads to simple benzoate derivatives in a process involving the formation of an N-aminopyrrole derivative, Diels-Alder reaction, and nitrene extrusion. The products are readily converted into isoquinolones through reaction with primary amines. The reaction proceeds best with highly substituted and electron-rich pyrroles even though these are the sterically least favorable substrates, and this reactivity trend is supported by a computational study.
费歇尔卡宾配合物、烯炔醛腙和缺电子炔烃的三组分偶联反应，在一个涉及形成N-氨基吡咯衍生物、狄尔斯-阿尔德反应和氮烯消除的过程中生成简单的苯甲酸酯衍生物。通过与伯胺反应，产物可很容易地转化为异喹啉酮。该反应在高度取代且富电子的吡咯存在下进行得最好，尽管这些是空间位阻最不利的底物，并且这种反应活性趋势得到了计算研究的支持。
