Shi Liangliang, Yu Ke, Wang Baiquan
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Chem Commun (Camb). 2015 Dec 18;51(97):17277-80. doi: 10.1039/c5cc05977a.
A mild and efficient Rh(III)-catalyzed regioselective synthesis of isoquinolones and pyridones has been developed. The protocol uses readily available N-methoxybenzamide or N-methoxymethacrylamide and diazo compounds as starting materials. The process involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, and the corresponding isoquinolone and pyridone derivatives were obtained in good to excellent yields with excellent regioselectivities. The process provides a facile approach for the construction of isoquinolone and pyridone derivatives containing various functional groups.
已开发出一种温和且高效的铑(III)催化的异喹啉酮和吡啶酮区域选择性合成方法。该方案使用易于获得的N-甲氧基苯甲酰胺或N-甲氧基甲基丙烯酰胺以及重氮化合物作为起始原料。涉及串联C-H活化、环化和缩合步骤的过程在温和条件下进行，并且以良好至优异的产率和优异的区域选择性获得了相应的异喹啉酮和吡啶酮衍生物。该方法为构建含有各种官能团的异喹啉酮和吡啶酮衍生物提供了一种简便的途径。
