Lupinacci Felipe S, Bussius Daniel, Acquesta Felipe, Fam Gustavo, Rossi Raphael, Navarini Alessandra, Mimica Marcelo J
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil.
J Lab Physicians. 2017 Oct-Dec;9(4):314-316. doi: 10.4103/JLP.JLP_161_16.
Clindamycin has become an important antimicrobial option for the treatment of . However, little is known about the current patterns of clindamycin-susceptibility in invasive isolates, both in our country and in other developing countries in the world.
The aim of this study was to determine the prevalence of constitutive and inducible clindamycin resistance in methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) blood culture isolates in São Paulo, Brazil.
From July 2011 to June 2012, all isolates from blood cultures collected at our hospital were included in the study. Antimicrobial susceptibility testing was performed according to recommendations of the Clinical and Laboratory Standards Institute.
Total prevalence of clindamycin resistance was 68%, including 7.2% with inducible resistance. In MRSA resistance rate was 90.8% whereas in MSSA the rate was 32.7%.
Our high prevalence of clindamycin resistance highlights the importance of performing D-test in a routine base, as well of maintaining continued surveillance for the prevalence of clindamycin resistance.
克林霉素已成为治疗……的一种重要抗菌药物选择。然而，在我国以及世界其他发展中国家，对于侵袭性分离株中克林霉素敏感性的当前模式了解甚少。
本研究的目的是确定巴西圣保罗甲氧西林敏感金黄色葡萄球菌（MSSA）和甲氧西林耐药金黄色葡萄球菌（MRSA）血培养分离株中组成型和诱导型克林霉素耐药的发生率。
2011年7月至2012年6月，我院采集的血培养中的所有金黄色葡萄球菌分离株均纳入本研究。抗菌药物敏感性试验按照临床和实验室标准协会的建议进行。
克林霉素耐药的总发生率为68%，其中诱导型耐药为7.2%。MRSA中的耐药率为90.8%，而MSSA中的耐药率为32.7%。
我们较高的克林霉素耐药发生率凸显了常规进行D试验以及持续监测克林霉素耐药发生率的重要性。
