Faculty of Health Sciences, Universiti Sultan Zainal Abidin, 21300 Kuala Nerus, Terengganu, Malaysia.
Faculty of Medicine, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, Malaysia.
J Med Microbiol. 2019 Sep;68(9):1299-1305. doi: 10.1099/jmm.0.000993.
The spread of multidrug-resistant is a public health concern. The inducible macrolide-lincosamide-streptogrammin B (iMLS ) phenotype (or inducible clindamycin resistance) is associated with false clindamycin susceptibility in routine laboratory testing and may lead to treatment failure. Tigecycline resistance remains rare in worldwide. This study aims to determine the antimicrobial susceptibility profiles of clinical isolates of obtained from the main tertiary hospital in Terengganu state, Malaysia, from July 2016 to June 2017. The antimicrobial susceptibilities of 90 methicillin-resistant (MRSA) and 109 methicillin-susceptible (MSSA) isolates were determined by disc diffusion with the iMLS phenotype determined by D-test. Multidrug resistance (MDR) and the iMLS phenotype were more prevalent in MRSA (84.4 and 46.7 %, respectively) compared to MSSA isolates. All five tigecycline-resistant isolates were MRSA. The high incidence of MDR and the iMLS phenotype and the emergence of tigecycline resistance in the Terengganu isolates warrants continuous vigilance.
耐多药 的传播是一个公共卫生关注点。诱导型大环内酯-林可酰胺-链阳菌素 B（iMLS）表型（或诱导型克林霉素耐药性）与常规实验室检测中的克林霉素假性敏感性相关，并可能导致治疗失败。替加环素耐药性在全球范围内仍然罕见。本研究旨在确定 2016 年 7 月至 2017 年 6 月从马来西亚登嘉楼州主要 tertiary 医院获得的临床分离株的抗菌药物敏感性谱。采用纸片扩散法测定 90 株耐甲氧西林金黄色葡萄球菌（MRSA）和 109 株甲氧西林敏感金黄色葡萄球菌（MSSA）分离株的抗菌药物敏感性，采用 D 试验测定 iMLS 表型。与 MSSA 分离株相比，MRSA 中更常见多重耐药性（MDR）和 iMLS 表型（分别为 84.4%和 46.7%）。所有五株替加环素耐药株均为 MRSA。登嘉楼分离株中 MDR 和 iMLS 表型的高发生率以及替加环素耐药性的出现需要持续警惕。
