Yagi T, Miyawaki Y, Nishikawa T, Yamauchi K, Kuwano S
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan.
J Pharm Pharmacol. 1988 Jan;40(1):27-30. doi: 10.1111/j.2042-7158.1988.tb05144.x.
Intracaecal administration of rhein anthrone, the intraluminally active metabolite of sennosides A and B, to mice quickly induced severe diarrhoea. Pretreatment with the prostaglandin (PG) biosynthesis inhibitor, indomethacin, and PGE2 antagonist, SC-19220, prevented the onset of diarrhoea induced by rhein anthrone, but the PGE2 antagonist polyphoretin phosphate (PPP) showed only a weak inhibitory effect. Rhein anthrone stimulated the production of PGE-like material only in the colon and its large intestinal propulsive activity was depressed by indomethacin and SC-19220, but not by PPP which suggests that the release of PGE-like material has some role in its purgative action.
向小鼠盲肠内给予番泻苷A和B的肠腔内活性代谢产物大黄素蒽酮，可迅速诱发严重腹泻。用前列腺素（PG）生物合成抑制剂吲哚美辛和PGE2拮抗剂SC - 19220进行预处理，可预防大黄素蒽酮诱发的腹泻发作，但PGE2拮抗剂聚磷酸根皮苷（PPP）仅显示出微弱的抑制作用。大黄素蒽酮仅在结肠中刺激PGE样物质的产生，其大肠推进活性被吲哚美辛和SC - 19220抑制，但不受PPP抑制，这表明PGE样物质的释放在其泻下作用中起一定作用。
