Yamauchi K, Yagi T, Kuwano S
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Pharmacology. 1993 Oct;47 Suppl 1:22-31. doi: 10.1159/000139839.
The involvement of Ca2+ in the mechanism of the purgative action of rhein anthrone was studied. Among individual or combination pretreatments with calcium channel blockers, calmodulin antagonists and prostaglandin biosynthesis inhibitors, the combination of indomethacin and nifedipine completely blocked the diarrhoea induced by rhein anthrone and also inhibited its effects on colonic fluid and electrolyte transport, and large intestinal motility. Calmodulin antagonists were less active regarding suppression of the effects of rhein anthrone. We concluded that, in addition to prostaglandins, diarrhoea induced by rhein anthrone must also involve the calcium channel which can be blocked by nifedipine, but not verapamil.
研究了Ca2+在大黄蒽酮泻下作用机制中的参与情况。在用钙通道阻滞剂、钙调蛋白拮抗剂和前列腺素生物合成抑制剂进行单独或联合预处理时，吲哚美辛和硝苯地平的联合使用完全阻断了大黄蒽酮诱导的腹泻，并且还抑制了其对结肠液体和电解质转运以及大肠运动的影响。钙调蛋白拮抗剂在抑制大黄蒽酮作用方面活性较低。我们得出结论，除了前列腺素外，大黄蒽酮诱导的腹泻还必须涉及可被硝苯地平而非维拉帕米阻断的钙通道。
