Karlberg A T, Bohlinder K, Boman A, Hacksell U, Hermansson J, Jacobsson S, Nilsson J L
Department of Occupational Dermatology, National Institute of Occupational Health, Stockholm, Sweden.
J Pharm Pharmacol. 1988 Jan;40(1):42-7. doi: 10.1111/j.2042-7158.1988.tb05147.x.
15-Hydroperoxyabietic acid (15-HPA) has been isolated from Portuguese colophony of the gum rosin type and identified as its methyl ester. The structure of the compound was elucidated using UV, IR, NMR and mass spectrometry. 15-HPA methyl ester was found to be an elicitor when tested in colophony-sensitized guinea-pigs. The sensitizing capacity was verified in the same species and 15-HPA methyl ester was considered to be a strong allergen. The eliciting potential was also verified in patients with known allergy to colophony. The Portuguese gum rosin investigated contained approximately 1% of 15-HPA. Based on its allergenicity and the amounts isolated, we conclude that 15-HPA is a main contact allergen in Portuguese gum rosin.
15-氢过氧化枞酸（15-HPA）已从葡萄牙脂松香型松香中分离出来，并鉴定为其甲酯。该化合物的结构通过紫外光谱、红外光谱、核磁共振光谱和质谱进行了阐明。15-HPA甲酯在松香致敏的豚鼠中进行测试时被发现是一种激发剂。在同一物种中验证了其致敏能力，15-HPA甲酯被认为是一种强过敏原。在已知对松香过敏的患者中也验证了其激发潜力。所研究的葡萄牙脂松香中约含1%的15-HPA。基于其致敏性和分离出的量，我们得出结论，15-HPA是葡萄牙脂松香中的主要接触过敏原。
