Department of Anesthesiology and Critical Care, PS ZOZ Wojewodzkie Centrum Medyczne w Opolu, Aleja Witosa 26, 45-418 Opole, Poland.
Department of Endocrinology, Szpital Wojewodzki w Opolu, ul. Kosnego 53, 45-372 Opole, Poland.
J Crit Care. 2018 Feb;43:294-299. doi: 10.1016/j.jcrc.2017.09.179. Epub 2017 Sep 22.
The objective of this study was to assess the vitamin D kinetics in critically ill patients by performing periodic serum vitamin D measurements in short time intervals in the initial phase of a critical illness.
We performed vitamin D serum measurements: at admission and then in 12-hour time intervals. The minimum number of vitamin D measurements was 4, and the maximum was 8 per patient.
A total of 363 patients were evaluated for participation, and 20 met the inclusion criteria. All patients had an initial serum vitamin D level between 10.6 and 39ng/mL. Nineteen patients had vitamin D levels between 10 and 30ng/mL, which means that they had vitamin D insufficiency or deficiency, and only one patient had a normal vitamin D serum plasma level. We observed that the median of the vitamin D level decreases until the fourth measurement then stabilizes around the 4th and 5th measurement and then appears to increase unevenly. The highest drop is at the very beginning.
The vitamin D serum level is changeable in the initial phase of a critical illness. We hypothesize that the serum vitamin D concentration can mirror the severity of illness.
本研究旨在通过在危重病的初始阶段定期进行短时间间隔的血清维生素 D 测量，评估危重病患者的维生素 D 动力学。
我们进行了维生素 D 血清测量：入院时，然后每 12 小时测量一次。每位患者的维生素 D 测量次数最少为 4 次，最多为 8 次。
共评估了 363 名患者参与，20 名符合纳入标准。所有患者的初始血清维生素 D 水平在 10.6 至 39ng/mL 之间。19 名患者的维生素 D 水平在 10 至 30ng/mL 之间，这意味着他们存在维生素 D 不足或缺乏，只有 1 名患者的血清维生素 D 血浆水平正常。我们观察到维生素 D 水平的中位数在第四次测量前一直下降，然后在第四次和第五次测量时稳定下来，然后似乎不均匀地增加。最高的下降发生在开始时。
在危重病的初始阶段，血清维生素 D 水平是变化的。我们假设血清维生素 D 浓度可以反映疾病的严重程度。
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