Singh Amandeep, Rath Goutam, Singh Ranjit, Goyal Amit K
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
Curr Drug Deliv. 2018 Feb 14;15(2):155-166. doi: 10.2174/1567201814666171002115230.
Electrospun nonwoven nanofibers are emerging as a novel carrier for verity of drugs meant for treatment of infections, disorders and tissue engineering scaffolds. These systems may used widely in controlled release of drug that are beneficial for the health management. Nonwoven structures may provide great surface area, absorbable, simplistic processing and economical. For water loving small molecule drugs, their high water solubility and poor partition and compatibility issues with polymers make it long term release yet more challenging.
Several strategies have been explored to control the release of hydrophilic drugs with high drug payload in electrospun fibers. Various techniques like blending, co-axial electrospinning can be used to improve drug payload.
Studies have suggested that electrospinning methods are important attributes of developed nanofibers. Further, types of polymers are also important contributory factor on drug load and release. This review gives an overview of nanofibers used for controlled and sustained release for drugs.
This articles enlightened that physicochemical and biological properties of nanofibers may be regulated by changing processing and formulation parameters.
电纺非织造纳米纤维正成为用于治疗感染、疾病和组织工程支架的多种药物的新型载体。这些系统可广泛用于药物的控释，这对健康管理有益。非织造结构可提供巨大的表面积、可吸收性、简单的加工过程且经济实惠。对于亲水性小分子药物，其高水溶性以及与聚合物的分配和相容性差的问题使得其长效释放更具挑战性。
已经探索了几种策略来控制电纺纤维中高载药量亲水性药物的释放。可以使用各种技术，如共混、同轴电纺来提高药物载量。
研究表明，电纺方法是所制备纳米纤维的重要属性。此外，聚合物类型也是影响药物负载和释放的重要因素。本综述概述了用于药物控释和缓释的纳米纤维。
本文表明，通过改变加工和配方参数可以调节纳米纤维的物理化学和生物学性质。
