Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
J Control Release. 2014 Nov 10;193:296-303. doi: 10.1016/j.jconrel.2014.04.025. Epub 2014 Apr 26.
Coaxial electrospinning is a robust technique for one-step encapsulation of fragile, water-soluble bioactive agents, including growth factors, DNA and even living organisms, into core-shell nanofibers. The coaxial electrospinning process eliminates the damaging effects due to direct contact of the agents with organic solvents or harsh conditions during emulsification. The shell layer serves as a barrier to prevent the premature release of the water-soluble core contents. By varying the structure and composition of the nanofibers, it is possible to precisely modulate the release of the encapsulated agents. Promising work has been done with coaxially electrospun non-woven mats integrated with bioactive agents for use in tissue engineering, in local delivery and in wound healing, etc. This paper reviews the origins of the coaxial electrospinning method, its updated status and potential future developments for controlled release of the class of fragile, water-soluble bioactive agents.
同轴静电纺丝是一种强大的技术，可将易碎的水溶性生物活性剂（包括生长因子、DNA 甚至生物体）一步封装到核壳纳米纤维中。同轴静电纺丝工艺消除了由于活性剂与有机溶剂直接接触或乳化过程中苛刻条件而导致的破坏性影响。壳层作为一种屏障，可防止水溶性核内容物过早释放。通过改变纳米纤维的结构和组成，可以精确调节封装剂的释放。已经有令人鼓舞的工作使用与生物活性剂集成的同轴静电纺无纺垫进行了组织工程、局部递送和伤口愈合等方面的研究。本文综述了同轴静电纺丝方法的起源、其最新现状和未来在控制释放易碎的水溶性生物活性剂方面的潜在发展。
