lncRNA BANCR的上调与结直肠癌的淋巴结转移及不良预后相关。
Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer.
作者信息
Shen Xiaogang, Bai Yifeng, Luo Bin, Zhou Xiaogang
机构信息
Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, 32 Second West Section of the First Ring Road, Chengdu, 610072, Sichuan, China.
Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 610072, Sichuan, China.
出版信息
Biol Res. 2017 Oct 2;50(1):32. doi: 10.1186/s40659-017-0136-5.
BACKGROUND
Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim of this study is to explore the clinical value of lncRNA BANCR in CRC patients.
METHODS
The expression of lncRNA BANCR was measured in 106 CRC tissues and 65 adjacent normal tissues using the quantitative real-time PCR.
RESULTS
The study showed that lncRNA BANCR was highly expressed in CRC tissues compared with adjacent normal tissues (P < 0.001). In addition, high expression of lncRNA BANCR was positively correlated with the lymph node metastasis (P < 0.001). Kaplan-Meier analysis showed that patients with high lncRNA BANCR expression had a shorter overall survival (OS) compared with the low lncRNA BANCR expression group (P = 0.001). Interestingly, for the group of patients with the lymph node metastasis, we found the similar result that high lncRNA BANCR expression was related to poor OS (P = 0.004). Furthermore, the multivariate Cox regression model analysis indicated that high expression of lncRNA BANCR was an independent poor prognostic factor in CRC patients (HR 2.24, 95% CI 1.22-4.16, P = 0.009).
CONCLUSIONS
Upregulation of lncRNA BANCR may be associated with the lymph node metastasis and poor survival of CRC. LncRNA BANCR could be served as a novel and useful biomarker for CRC lymph node metastasis and prognosis.
背景
越来越多的证据支持长链非编码RNA（lncRNAs）在结直肠癌（CRC）的发生、发展和预后中发挥重要作用。然而，关于BRAF激活的非编码RNA（BANCR）在CRC中的临床意义知之甚少。本研究旨在探讨lncRNA BANCR在CRC患者中的临床价值。
方法
采用定量实时PCR检测106例CRC组织和65例癌旁正常组织中lncRNA BANCR的表达。
结果
研究表明，与癌旁正常组织相比，lncRNA BANCR在CRC组织中高表达（P < 0.001）。此外，lncRNA BANCR的高表达与淋巴结转移呈正相关（P < 0.001）。Kaplan-Meier分析显示，lncRNA BANCR高表达患者的总生存期（OS）较lncRNA BANCR低表达组短（P = 0.001）。有趣的是，在有淋巴结转移的患者组中，我们发现了类似的结果，即lncRNA BANCR高表达与较差的OS相关（P = 0.004）。此外，多因素Cox回归模型分析表明，lncRNA BANCR高表达是CRC患者独立的不良预后因素（HR 2.24，95%CI 1.22 - 4.16，P = 0.009）。
结论
lncRNA BANCR的上调可能与CRC的淋巴结转移和不良生存相关。LncRNA BANCR可作为CRC淋巴结转移和预后的一种新的有用生物标志物。
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