Shamshad Ghassan Umair, Salamat Nuzhat, Umair Muhammad
Department of Pathology, Combined Military Hospital Bannu, Bannu Cantonment.
Department of Pathology, PNS Shifa, Karachi.
J Coll Physicians Surg Pak. 2017 Sep;27(9):S92-S94.
We report a case of secondary cold agglutinin disease (CAD) due to pulmonary tuberculosis in a 68-year male patient who presented with acrocyanosis involving both upper limbs and greater portion of lower limbs. Direct Coombs' test was positive with mild anemia and the cold agglutinin titer was high. Sputum showed numerous acid fast bacilli per high power field. The patient was given standard anti-tuberculous treatment (ATT) and his symptoms gradually improved. After nine months of ATT, his haemoglobin improved, acrocyanosis resolved completely and cold agglutinin titer decreased in level.
我们报告一例68岁男性患者因肺结核导致的继发性冷凝集素病（CAD），该患者表现为双侧上肢及大部分下肢发绀。直接抗人球蛋白试验呈阳性，伴有轻度贫血，冷凝集素效价较高。痰涂片每高倍视野可见大量抗酸杆菌。患者接受了标准抗结核治疗（ATT），症状逐渐改善。抗结核治疗9个月后，患者血红蛋白水平提高，发绀完全消退，冷凝集素效价降低。
