Baltà Cruz S, Moreno Ribera N, Estrach Panella M T
Departamento de Dermatología, Hospital Clínic Barcelona, Universitat de Barcelona, Barcelona, España.
Departamento de Dermatología, Hospital Clínic Barcelona, Universitat de Barcelona, Barcelona, España.
Actas Dermosifiliogr (Engl Ed). 2018 Jan-Feb;109(1):58-62. doi: 10.1016/j.ad.2017.06.013. Epub 2017 Sep 30.
Although Mercromina Film and other topical antiseptics are widely used, they are not included in the standard series recommended by the Spanish Contact Dermatitis and Skin Allergy Research Group for testing suspected allergic contact dermatitis (ACD). Furthermore, no recent studies have investigated the allergenic potential of merbromin.
To determine the allergenic potential of merbromin and compare it with that of other topical antiseptics widely used in clinical practice, including povidone-iodine, chlorhexidine, and eosin.
Prospective single-center observational safety study of 105 patients with suspected ACD seen at the dermatology department of our hospital.
Of the 105 patients studied, 1.9% had a positive patch test to merbromin and 12.4% were sensitized to povidone-iodine. The differences in the proportion of patients with ACD to Betadine Solución Dérmica (povidone-iodine) compared with the rest of the antiseptics was statistically significant (McNemar test, P<.05). No adverse reactions were observed in any of the patients.
Based on the patch tests conducted, Mercromina Film has very low allergenic potential. The highest allergenic potential was observed for povidone-iodine.
尽管汞溴红膜剂和其他外用防腐剂被广泛使用，但它们并未被西班牙接触性皮炎和皮肤过敏研究小组推荐用于检测疑似过敏性接触性皮炎（ACD）的标准系列中。此外，最近没有研究调查过汞溴红的致敏潜力。
确定汞溴红的致敏潜力，并将其与临床实践中广泛使用的其他外用防腐剂（包括聚维酮碘、氯己定和伊红）的致敏潜力进行比较。
对我院皮肤科就诊的105例疑似ACD患者进行前瞻性单中心观察性安全性研究。
在研究的105例患者中，1.9%的患者对汞溴红斑贴试验呈阳性，12.4%的患者对聚维酮碘致敏。与其他防腐剂相比，对聚维酮碘溶液（聚维酮碘）发生ACD的患者比例差异具有统计学意义（McNemar检验，P<0.05）。未观察到任何患者出现不良反应。
基于所进行的斑贴试验，汞溴红膜剂的致敏潜力非常低。观察到聚维酮碘的致敏潜力最高。
