Darrigade A S, Léauté-Labrèze C, Boralevi F, Taïeb A, Milpied B
Department of Adult and Pediatric Dermatology, Bordeaux University Hospitals, Bordeaux, France.
J Eur Acad Dermatol Venereol. 2018 Dec;32(12):2284-2287. doi: 10.1111/jdv.15140. Epub 2018 Jul 31.
Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children.
To evaluate contact allergic dermatitis to antiseptics in young children.
The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an antiseptics series and the personal topical products used.
Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive.
These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common antiseptics in non-atopic children. We hypothesize that the systematic use of antiseptics for umbilical cord care could be responsible for the sensitization in newborns.
外用防腐剂引起的接触性皮炎大多在成人中报道，但也有少数幼儿氯己定接触性皮炎的病例。
评估幼儿对抗菌剂的接触性过敏性皮炎。
对主要因误诊（蜂窝织炎）转诊的儿童进行了一系列检测，包括欧洲基线系列、抗菌剂系列以及个人使用的外用产品。
2010年5月至2017年12月期间，14名儿童（8名男孩，6名女孩）被诊断为对抗菌剂接触性皮炎。确诊时的平均年龄为38个月（8个月至8岁）；只有3名儿童有特应性个人史。7例葡萄糖酸氯己定呈阳性，8例苯扎氯铵呈阳性，4例两种变应原均呈阳性。
这些小病例系列证实，氯己定和苯扎氯铵均与儿科人群因使用抗菌剂引起的接触性皮炎有关。我们强调这些患者最初的误诊、儿童的低龄以及非特应性儿童中常见抗菌剂的致敏潜力。我们推测，新生儿系统性使用抗菌剂进行脐带护理可能是导致致敏的原因。
