SAMHD1 为 DNA 双链断裂修复带来曙光。
SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair.
机构信息
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre Building, 555 Wilmslow Road, Manchester M20 4GJ, UK.
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre Building, 555 Wilmslow Road, Manchester M20 4GJ, UK.
出版信息
Trends Genet. 2017 Dec;33(12):895-897. doi: 10.1016/j.tig.2017.09.007. Epub 2017 Sep 29.
SAMHD1 (sterile α motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DSBs) by promoting recruitment of C-terminal binding protein interacting protein (CTIP), a DNA-end resection factor, to damaged DNA. These findings could benefit anticancer treatment.
SAMHD1（无酶性α基序和天冬氨酸（D）域包含蛋白 1）以其水解病毒复制所需的脱氧核苷酸的抗病毒活性而闻名。Daddacha 等人发现了 SAMHD1 的一种非水解酶、兼职功能，通过促进 DNA 末端切除因子 C-terminal binding protein interacting protein（CTIP）与受损 DNA 的募集，促进 DNA 双链断裂（DSB）的同源重组。这些发现可能有益于癌症治疗。
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