Endocrinology and Metabolism Department, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, P.R. China.
Sci Rep. 2017 Oct 2;7(1):12531. doi: 10.1038/s41598-017-12921-3.
The purpose of this study is to analyse the association between gestational weight gain and delivery outcome or the morbidity of pregnancy complications. A total of 1,102 pregnant women who delivered at Peking University People's Hospital in China between January 2011 and December 2012 were included in this study. We divided them into 4 groups according to the baseline BMI quartiles and weight gain quartiles in different trimesters of pregnancy to analyse the status of delivery outcome and morbidity of pregnancy complications. Baseline BMI was significantly positive correlated with the morbidity of gestational hypertension and gestational diabetes. Weight gain in the second trimester of pregnancy was significantly positively correlated with the morbidity of macrosomia. Weight gain in the third trimester of pregnancy showed significantly positive correlation with the morbidity of macrosomia, and significantly negative correlation with the morbidity of neonatal death, preterm birth, gestational diabetes, and low birth-weight infant. Gestational weight gain showed significantly positive correlation with the morbidity of macrosomia and significantly negative correlation with neonatal death, stillbirth, gestational diabetes, preterm birth and low birth-weight infant. There is a correlation between baseline BMI, pregnancy weight gain and gestational complications, adverse pregnancy outcomes, and status of neonate in varying degrees.
本研究旨在分析妊娠期体重增加与分娩结局或妊娠并发症发病率之间的关系。该研究共纳入了 2011 年 1 月至 2012 年 12 月期间在中国北京大学人民医院分娩的 1102 名孕妇。我们根据基线 BMI 四分位和妊娠不同时期体重增加四分位将其分为 4 组，分析分娩结局和妊娠并发症发病率的状况。基线 BMI 与妊娠期高血压和妊娠期糖尿病的发病率呈显著正相关。妊娠中期体重增加与巨大儿的发病率呈显著正相关。妊娠晚期体重增加与巨大儿的发病率呈显著正相关，与新生儿死亡、早产、妊娠期糖尿病和低出生体重儿的发病率呈显著负相关。妊娠期体重增加与巨大儿的发病率呈显著正相关，与新生儿死亡、死胎、妊娠期糖尿病、早产和低出生体重儿的发病率呈显著负相关。基线 BMI、妊娠体重增加与妊娠并发症、不良妊娠结局和新生儿状况之间存在不同程度的相关性。
