Wu Kui, Gong Wei, Ke Hui-Hui, Hu Hua, Chen Li
Department of Obstetrics and Gynecology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai 201399, China.
Heliyon. 2022 Nov 23;8(11):e11806. doi: 10.1016/j.heliyon.2022.e11806. eCollection 2022 Nov.
Increased white blood cell count (WBC) is known to be associated with preeclampsia (PE). This study aimed to determine whether WBC count >10×10/L had significant impact on late-onset PE (LOPE) during the first and second trimesters.
This prospective study was conducted in 600 pregnant women from Shanghai Pudong Hospital in China from July 2019 to August 2020. They were classified into four groups: Group 1: WBC count ≤10×10/L at 10th-12th week and 24th-26th week; Group 2, WBC count ≤10×10/L at 10th-12th week but WBC count >10×10/L at 24th-26th week; Group 3, WBC count >10×10/L at 10th-12th week but WBC count≤10×10/L at 24th-26th week; Group 4, WBC count >10×10/L at 10th-12th week and 24th-26th week. Complete blood count results from 10th-12th week and 24th-26th week were obtained for each patient. Maternal laboratory values including white blood cell (WBC) count were compared between the four groups.
34 women were diagnosed with LOPE at predelivery. The estimated incidence rate of LOPE during pregnancy was 3.6% in Group 1, 5.8% in Group 2, 7.2% in Group 3, and 11% in Group 4 for the respective WBC level of Group 1, 2, 3 and 4. After adjusting for potential influencing factors of PE, the respective relative risks for LOPE was 1.0 (reference), 1.76 (95% CI 0.37, 8.30), 2.23 (0.85, 5.89), and 3.07 (1.34, 7.02) (P for trend = 0.048).
Our results demonstrated that WBC count >10×10/L during the first and second trimesters is a risk of LOPE.
已知白细胞计数（WBC）升高与子痫前期（PE）相关。本研究旨在确定妊娠前三个月和第二个三个月期间白细胞计数>10×10⁹/L是否对晚发型子痫前期（LOPE）有显著影响。
本前瞻性研究于2019年7月至2020年8月在中国上海浦东医院的600名孕妇中进行。她们被分为四组：第1组：孕10 - 12周和24 - 26周时白细胞计数≤10×10⁹/L；第2组，孕10 - 12周时白细胞计数≤10×10⁹/L，但孕24 - 26周时白细胞计数>10×10⁹/L；第3组，孕10 - 12周时白细胞计数>10×10⁹/L，但孕24 - 26周时白细胞计数≤10×10⁹/L；第4组，孕10 - 12周和24 - 26周时白细胞计数>10×10⁹/L。获取每位患者孕10 - 12周和24 - 26周的全血细胞计数结果。比较四组之间包括白细胞（WBC）计数在内的母体实验室值。
34名女性在分娩前被诊断为LOPE。对于第1、2、3和4组各自的白细胞水平，第1组妊娠期间LOPE的估计发病率为3.6%，第2组为5.8%，第3组为7.2%，第4组为11%。在调整PE的潜在影响因素后，LOPE的各自相对风险为1.0（参考值），1.76（95%CI 0.37，8.30），2.23（0.85，5.89）和3.07（1.34，7.02）（趋势P值 = 0.048）。
我们的结果表明，妊娠前三个月和第二个三个月期间白细胞计数>10×10⁹/L是发生LOPE的一个风险因素。
