Aiello Salvatore, Loomba Rohit S, Kriz Connor, Buelow Matthew, Aggarwal Saurabh, Arora Rohit R
Division of Cardiology, Chicago Medical School, North Chicago, IL, USA.
Division of Cardiology, Children's Hospital of Wisconsin/Medical College of Wisconsin, Milwaukee, WI, USA.
Indian J Crit Care Med. 2017 Sep;21(9):547-551. doi: 10.4103/ijccm.IJCCM_169_17.
Adults with congenital heart disease (ACHD) represent a population with unique health-care needs. Many patients require cardiac surgery, with some requiring postoperative extracorporeal membrane oxygenation (ECMO). This study aimed to identify the risk factors for the need of postoperative ECMO and characterize the impact of ECMO on admission characteristics.
Data from the 2005-2012 iterations of the Nationwide Inpatient Sample were used. ACHD admissions over 18 years with a documented cardiac surgery were included. Univariate analysis was conducted to compare the characteristics between those requiring ECMO and those who did not. Regression analysis was done to identify the independent risk factors associated with ECMO and to determine the impact of ECMO on length, cost, and mortality of the admission.
A total of 186,829 admissions were included. Of these, 446 (0.2%) admissions required ECMO. Those with acute kidney injury, double-outlet right ventricle, or total anomalous pulmonary venous connection were more likely to require ECMO. ECMO was also significantly more utilized in patients undergoing septal defect repair, complete repair of tetralogy of Fallot, atrial switch, and heart transplant. The use of ECMO significantly increased length, cost, and mortality of stay. Overall mortality was 62.6% in the ECMO group.
ECMO is only needed in a small proportion of postoperative ACHD patients. The use of ECMO significantly increases cost, length of stay and mortality in these patients. Improved identification of postoperative ACHD patients who are more likely to survive ECMO may facilitate improved survival and decreased resource utilization.
患有先天性心脏病的成年人(ACHD)是一个有独特医疗需求的群体。许多患者需要进行心脏手术,部分患者术后还需要体外膜肺氧合(ECMO)。本研究旨在确定术后需要ECMO的风险因素,并描述ECMO对入院特征的影响。
使用2005 - 2012年全国住院患者样本的数据。纳入18岁以上有心脏手术记录的ACHD住院患者。进行单因素分析以比较需要ECMO的患者和不需要ECMO的患者的特征。进行回归分析以确定与ECMO相关的独立风险因素,并确定ECMO对住院时间、费用和死亡率的影响。
共纳入186,829例住院患者。其中,446例(0.2%)住院患者需要ECMO。患有急性肾损伤、右心室双出口或完全性肺静脉异位连接的患者更有可能需要ECMO。在进行室间隔缺损修复、法洛四联症完全修复、心房调转术和心脏移植的患者中,ECMO的使用也显著更多。ECMO的使用显著增加了住院时间、费用和死亡率。ECMO组的总体死亡率为62.6%。
只有一小部分ACHD术后患者需要ECMO。ECMO的使用显著增加了这些患者的费用、住院时间和死亡率。更好地识别更有可能在ECMO治疗后存活的ACHD术后患者,可能有助于提高生存率并减少资源利用。