Katafuchi T, Oomura Y, Kurosawa M
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Neurosci Lett. 1988 Mar 31;86(2):195-200. doi: 10.1016/0304-3940(88)90570-8.
The effects of stimulation of the hypothalamic paraventricular nucleus (PVN) by L-glutamate on blood pressure and ongoing activities of adrenal and renal sympathetic nerves were examined in anesthetized rats. Microinjection of excitatory amino acid, L-glutamate (100 nmol in 200 nl saline), into the unilateral PVN resulted in an increase in the ipsilateral adrenal nerve activity, while it resulted in decreases in renal nerve activity and arterial blood pressure. After severance of bilateral carotid sinus and vagal nerves, the decreased response of blood pressure to the same stimulus did not change, while the decreased response of renal nerve activity was almost abolished, and the increased response of adrenal nerve activity still remained, though it slightly attenuated. The involvements of baroreceptor afferents and vagal afferents in these responses were discussed.
在麻醉大鼠中，研究了L-谷氨酸刺激下丘脑室旁核（PVN）对血压以及肾上腺和肾交感神经活动的影响。向单侧PVN微量注射兴奋性氨基酸L-谷氨酸（200 nl盐水中含100 nmol），可导致同侧肾上腺神经活动增加，而肾神经活动和动脉血压降低。切断双侧颈总动脉窦和迷走神经后，血压对相同刺激的降低反应未改变，而肾神经活动的降低反应几乎消失，肾上腺神经活动的增加反应仍存在，尽管略有减弱。讨论了压力感受器传入纤维和迷走神经传入纤维在这些反应中的作用。
