Yamashita H, Kannan H, Kasai M, Osaka T
J Auton Nerv Syst. 1987 Jun;19(3):229-34. doi: 10.1016/0165-1838(87)90069-5.
Effects of electrical and chemical stimulation of the paraventricular nucleus (PVN) of the hypothalamus on blood pressure were examined in rats anesthetized with urethane-chloralose. Focal electrical stimulation (10-25 microA, 50 Hz, 0.5 ms) of sites within the PVN consistently decreased blood pressure, while the stimulation of regions adjacent to the PVN produced no change or weak depressor response. Microinjection of L-glutamate (0.5 M, 80 nl) to the PVN consistently led to decreased blood pressure, while the same amount of saline injection had no effect. The depressor response was not affected by cervical vagotomy but was markedly reduced after intravenous administration of hexamethonium. The results suggest that activation of PVN neurons in rats leads to a decrease in blood pressure.
在用乌拉坦-氯醛糖麻醉的大鼠中，研究了下丘脑室旁核（PVN）的电刺激和化学刺激对血压的影响。对PVN内的位点进行局部电刺激（10 - 25微安，50赫兹，0.5毫秒）持续降低血压，而对PVN相邻区域的刺激未产生变化或产生微弱的降压反应。向PVN微量注射L-谷氨酸（0.5 M，80纳升）持续导致血压降低，而注射等量的生理盐水则无影响。降压反应不受颈迷走神经切断术的影响，但在静脉注射六甲铵后明显减弱。结果表明，大鼠PVN神经元的激活导致血压下降。
