与难治性白塞病相关的HLA - D区域限制性片段。

An HLA-D region restriction fragment associated with refractory Behçet's disease.

作者信息

Numaga J, Matsuki K, Mochizuki M, Minami M, Juji T

机构信息

Department of Ophthalmology, Tokyo University School of Medicine, Japan.

出版信息

Am J Ophthalmol. 1988 May 15;105(5):528-33. doi: 10.1016/0002-9394(88)90246-2.

DOI:10.1016/0002-9394(88)90246-2

PMID:2897165

Abstract

We examined the association between HLA-DQ and refractory Behçet's disease at the genomic DNA level. Using a restriction endonuclease Taq I and a DQ beta cDNA probe, we identified the 1.9 kb DQ beta restriction endonuclease fragment tightly associated with refractory Behçet's disease. This observation indicates that genomic HLA-DQ variations affect the development of refractory Behçet's disease.

摘要

我们在基因组DNA水平上研究了HLA-DQ与难治性白塞病之间的关联。使用限制性内切酶Taq I和DQβ cDNA探针，我们鉴定出了与难治性白塞病紧密相关的1.9 kb DQβ限制性内切酶片段。这一观察结果表明，基因组HLA-DQ变异会影响难治性白塞病的发展。