睾丸生殖细胞肿瘤中新发现的分子靶点的最新进展。
Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors.
机构信息
Dipartimento di Psicologia, Universita degli Studi della Campania, 81100 Caserta, Italy.
出版信息
Curr Med Chem. 2018 Feb 13;25(5):575-583. doi: 10.2174/0929867324666171003115807.
BACKGROUND
Testicular germ cell tumor (TGCT) is the most common solid malignancy occurring in young men between 20 and 34 years of age, and its incidence has increased significantly over the last decades. TGCTs can be subdivided into seminoma and nonseminoma germ cell tumors (NSGCTs), which includes yolk sac tumor, choriocarcinoma, embryonal cell carcinoma, and teratoma. Seminomas and NSGCTs present significant differences in therapy, prognosis, and both show characteristics of the Primordial Germ Cells (PGCs).
METHODS
I undertook a search of bibliographic data from peer-reviewed research literature.
RESULTS
Seventy papers were included in the mini-review showing that a large number of new biomarkers have given further advantages to discriminate the different histotypes and could represent useful novel molecular targets for anticancer strategies.
CONCLUSION
A deeper understanding of the pathogenesis of TGCTs is likely to significantly improve not only our knowledge on stem cells and oncogenesis but also the disease management with more selective tumor treatment.
背景
睾丸生殖细胞肿瘤（TGCT）是 20 至 34 岁年轻男性中最常见的实体恶性肿瘤，在过去几十年中其发病率显著增加。TGCT 可分为精原细胞瘤和非精原细胞瘤生殖细胞肿瘤（NSGCT），包括卵黄囊肿瘤、绒毛膜癌、胚胎细胞癌和畸胎瘤。精原细胞瘤和 NSGCT 在治疗、预后方面存在显著差异，两者均表现出原始生殖细胞（PGC）的特征。
方法
我对同行评议的研究文献中的文献数据进行了检索。
结果
该迷你综述共纳入 70 篇论文，表明大量新的生物标志物进一步有助于区分不同的组织类型，并可能成为抗癌策略的有用新的分子靶点。
结论
对 TGCT 发病机制的深入了解不仅可能显著提高我们对干细胞和肿瘤发生的认识，而且还可能通过更具选择性的肿瘤治疗来改善疾病管理。
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