Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Rajiv Gandhi South Campus, Banaras Hindu University - Ayurveda Pharmacy Research Laboratory Mirzapur, Uttar Pradesh, India.
Mini Rev Med Chem. 2018;18(13):1095-1109. doi: 10.2174/1389557517666170927144119.
Mushrooms have been used as traditional medicine from last few decades. Mushrooms as higher Basidiomycetes contain secondary metabolites in fruit bodies, cultured mycelium, and cultured broth. Medicinal mushrooms possess medicinal properties such as anti-tumor, immunomodulating, antioxidant, cardiovascular, anti-hypercholesterolemic, anti-viral, anti-bacterial, anti-parasitic, antifungal, detoxification, hepatoprotective, and anti-diabetic effects. Phase-I, II, and III clinical trials were studied on various biologically active compounds isolated from medicinal mushrooms and are used adequately to treat various diseases including cancer. The present review focuses on various edible, medicinal and poisonous species of mushrooms belong to genera; Auricularia, Cantherallus, Ganoderma, Pleurotus, Lentinus, Trametes (Coriolus), Tremella and Amanita along with their chemical composition, biologically active compounds isolated and their pharmacological potential.
几十年来，蘑菇一直被用作传统药物。作为高等担子菌的蘑菇在子实体、培养菌丝体和培养肉汤中含有次生代谢产物。药用蘑菇具有药用特性，如抗肿瘤、免疫调节、抗氧化、心血管、降胆固醇、抗病毒、抗菌、抗寄生虫、抗真菌、解毒、保肝和抗糖尿病作用。对从药用蘑菇中分离出的各种具有生物活性的化合物进行了 I、II 和 III 期临床试验，并充分用于治疗包括癌症在内的各种疾病。本综述重点介绍了属于 Auricularia、Cantherallus、Ganoderma、Pleurotus、Lentinus、Trametes（Coriolus）、Tremella 和 Amanita 属的各种可食用、药用和有毒蘑菇的种类，以及它们的化学成分、分离出的生物活性化合物及其药理学潜力。
