Department of Chemistry, Sabang Sajanikanta Mahavidyalaya, Lutunia, Paschim Medinipur, 721166 West Bengal, India.
Department of Chemistry, Government General Degree College, Salboni, Paschim Medinipur, 721516 West Bengal, India.
Int J Biol Macromol. 2021 Mar 1;172:408-417. doi: 10.1016/j.ijbiomac.2021.01.081. Epub 2021 Jan 16.
Mushrooms are renewable natural gift for humankind, furnished with unique taste, flavor and medicinal properties. For the last few decades study of mushroom polysaccharides has become a matter of great interest to the researchers for their immunomodulating, antimicrobial, antioxidant, anticancer, and antitumor properties. Molecular mass, branching configuration, conformation of polysaccharides and chemical modification are the major factors influencing their biological activities. The mechanism of action of mushroom polysaccharides is to stimulate T-cells, B-cells, natural killer cells, and macrophage dependent immune responses via binding to receptors like the toll-like receptor-2, dectin-1. The present review offers summarized and significant information about the structural and biological properties of mushroom polysaccharides, and their potential for development of therapeutic materials.
蘑菇是人类可永续利用的天然礼物，具有独特的口感、风味和药用价值。在过去的几十年里，蘑菇多糖的研究因其免疫调节、抗菌、抗氧化、抗癌和抗肿瘤特性而引起了研究人员的极大兴趣。多糖的分子量、支化结构、构象和化学修饰是影响其生物活性的主要因素。蘑菇多糖的作用机制是通过与 Toll 样受体-2、dectin-1 等受体结合，刺激 T 细胞、B 细胞、自然杀伤细胞和巨噬细胞依赖的免疫反应。本综述提供了关于蘑菇多糖的结构和生物学特性及其作为治疗材料开发潜力的总结性和重要信息。
