丙氨酸消旋酶突变在结核分枝杆菌 D-环丝氨酸耐药中的作用。
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
机构信息
Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
出版信息
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01575-17. Print 2017 Dec.
A screening of more than 1,500 drug-resistant strains of revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
对 1500 多种耐药株进行筛选，揭示了三个丙氨酸 racemase (Alr) 突变呈阳性选择特征的进化模式。我们使用分子建模、MIC 测试以及酶活性的直接测量来研究这些突变，结果表明这些突变可能导致对 d-环丝氨酸的耐药性。
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