Freed W J, Cannon-Spoor H E
Preclinical Neurosciences Section, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032.
Brain Res. 1988 Apr 12;446(1):133-43. doi: 10.1016/0006-8993(88)91303-0.
Effects of aspiration lesions of the cerebral cortex on intraventricular substantia nigra grafts were investigated. Increased reinnervation of the dorsal striatum was observed in animals with cortical aspirations. This reinnervation was confined to the dorsal one-fourth of the striatum, immediately underneath the cortical lesions. The increased reinnervation of the striatum by substantia nigra grafts in animals with cortical lesions is suggested to be related either to secretion of neurotrophic substances by the injured brain tissue or to removal of competition between corticostriatal inputs and graft-derived neurites for synaptic contacts.
研究了大脑皮质抽吸损伤对脑室内黑质移植的影响。在进行皮质抽吸的动物中观察到背侧纹状体的再支配增加。这种再支配局限于纹状体的背侧四分之一，紧挨着皮质损伤部位。皮质损伤动物中黑质移植对纹状体再支配增加，这被认为要么与受损脑组织分泌神经营养物质有关，要么与去除皮质纹状体输入和移植衍生神经突之间对突触接触的竞争有关。
