Bertrand J H, Ritz P, Reznik Y, Grollier G, Potier J C, Evrad C, Mahoudeau J A
Department of Cardiology, Centre Hospitalo-Universitaire de Caen, France.
Clin Endocrinol (Oxf). 1987 Nov;27(5):607-14. doi: 10.1111/j.1365-2265.1987.tb01191.x.
A 26-year-old male presented with the symptoms and signs of acute congestive heart failure and hypertension. The left ventricle was shown to be thickened and displayed reversible hypokinesia. Further investigations revealed the underlying pathology of a phaeochromocytoma, bilateral medullary thyroid carcinoma (MTC), parathyroid adenoma and macro-prolactinoma. There was a family history of MTC. The echocardiographic features of catecholamine-induced cardiomyopathy were important in this diagnosis. Our research revealed no previous report of Sipple's syndrome associated with a macroprolactinoma. This case, along with the other 13 reports of mixed (type I and II) multiple endocrine neoplasia (MEN), are not within the classical subsets of MEN.
一名26岁男性出现急性充血性心力衰竭和高血压的症状及体征。检查显示左心室增厚并伴有可逆性运动功能减退。进一步检查发现潜在病因是嗜铬细胞瘤、双侧甲状腺髓样癌（MTC）、甲状旁腺腺瘤和大泌乳素瘤。患者有MTC家族史。儿茶酚胺诱导性心肌病的超声心动图特征对该诊断很重要。我们的研究发现此前并无关于伴有大泌乳素瘤的西普尔综合征的报道。该病例以及其他13例混合性（I型和II型）多发性内分泌肿瘤（MEN）报告并不属于MEN的典型亚型。
