母亲糖尿病与子代儿童急性淋巴细胞白血病风险。
Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring.
机构信息
Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
Department of Public Health, University of Copenhagen, Copenhagen DK-1123, Denmark.
出版信息
Br J Cancer. 2018 Jan;118(1):117-120. doi: 10.1038/bjc.2017.351. Epub 2017 Oct 3.
Abstract
BACKGROUND
Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.
METHODS
We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).
RESULTS
Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.
CONCLUSIONS
Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.
摘要
背景
母体糖尿病可能与后代儿童急性淋巴细胞白血病（ALL）有关。
方法
我们在一项基于登记的研究中评估了母体孕前或孕期糖尿病与后代儿童 ALL 风险之间的关联，该研究纳入了 1996 年至 2015 年期间在丹麦出生的所有单胎（n=1187482）。
结果
调整后的儿童 ALL 风险比为 2.91（95%置信区间：1.30-6.51），母体孕前糖尿病为 2.91，母体孕期糖尿病为 1.75（95%置信区间：1.02-2.98）。父亲的糖尿病并未改变后代 ALL 的风险，我们也没有发现后代 ALL 与母亲后期糖尿病风险之间的关联。
结论
尽管糖尿病女性后代的 ALL 绝对风险仍然较低，但我们的研究结果表明，糖尿病宫内环境的特征促进了 ALL 的发展。这为研究儿童 ALL 背后的生物学机制提供了一个环境。
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