意大利北部基于人群的研究：母孕前糖尿病与后代急性淋巴细胞白血病风险。
Maternal pregestational diabetes and risk of acute lymphoblastic leukemia in the offspring: A population-based study in Northern Italy.
机构信息
Environmental, Genetic and Nutritional Epidemiology Research Centre (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287, 41125 Modena, Italy.
Department of Paediatrics, Sant'Orsola Hospital, University of Bologna, Via Giuseppe Massarenti, 9, 40138 Bologna, Italy.
出版信息
Cancer Epidemiol. 2019 Oct;62:101572. doi: 10.1016/j.canep.2019.101572. Epub 2019 Jul 20.
INTRODUCTION
This population-based study aims to evaluate the association between maternal pregestational diabetes and risk of acute lymphoblastic leukemia (ALL) in the offspring.
METHODS
All 241,958 children born in three Northern Italy provinces 1998-2010 were followed from birth until first cancer diagnosis (National Childhood Cancer Register), age 15 years, or 31 December 2017. We computed hazard ratio (HR) and 95% CI of ALL in relation to the presence of maternal diabetes through Cox proportional regression models.
RESULTS
We observed 145 cases of ALL, with a higher incidence in children born to women with pregestational diabetes compared to the others (12.4 vs 4.6). Adjusted hazard ratio of ALL was 2.6 (CI, 0.6-10.5) for maternal diabetes.
DISCUSSION
We estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
简介
本基于人群的研究旨在评估母亲孕前糖尿病与后代急性淋巴细胞白血病（ALL）风险之间的关联。
方法
1998 年至 2010 年，在意大利北部三个省份出生的所有 241958 名儿童从出生开始随访，直至首次癌症诊断（国家儿童癌症登记处）、15 岁或 2017 年 12 月 31 日。我们通过 Cox 比例风险回归模型计算了与母亲糖尿病存在相关的 ALL 的风险比（HR）和 95%置信区间。
结果
我们观察到 145 例 ALL，与其他儿童相比，母亲患有孕前糖尿病的儿童发病率更高（12.4 比 4.6）。校正后的 ALL 风险比为 2.6（95%CI，0.6-10.5）。
讨论
我们估计患有孕前糖尿病的女性的后代 ALL 风险更高。这些结果与先前的研究结果一致，与产前血糖环境在儿童癌症病因学中的作用相一致。
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