Scholz Malte, Reske Thomas, Böhmer Femke, Hornung Anne, Grabow Niels, Lang Hermann
Department of Operative Dentistry and Periodontology, Rostock University Medical Center, Rostock, Germany.
Institute for Biomedical Engineering, University of Rostock, Rostock, Germany.
PLoS One. 2017 Oct 3;12(10):e0185562. doi: 10.1371/journal.pone.0185562. eCollection 2017.
Periodontitis is one of the most common infectious diseases globally that, if untreated, leads to destruction of the tooth supporting tissues and finally results in tooth loss. Evidence shows that standard procedures as mechanical root cleaning could be supported by further treatment options such as locally applied substances. Due to gingival crevicular fluid flow, substances are commonly washed out off the periodontal pockets. The evaluation of administration techniques and the development of local drug releasing devices is thus an important aspect in periodontal research. This study describes the development and examination of a new alginate based, biodegradable and easily applicable drug delivery system for chlorhexidine (CHX). Different micro beads were produced and loaded with CHX and the release profiles were investigated by high performance liquid chromatography (HPLC). The in vitro-demonstrated release of CHX from alginate based beads shows comparable releasing characteristics as clinically approved systems. Yet many characteristics of this new delivery system show to be favourable for periodontal therapy. Easy application by injection, low production costs and multifunctional adaptions to patient related specifics may improve the usage in routine care.
牙周炎是全球最常见的传染病之一，如果不加以治疗，会导致牙齿支持组织遭到破坏，最终导致牙齿脱落。有证据表明，作为机械性牙根清洁的标准程序，可以通过诸如局部应用药物等进一步的治疗方法来辅助。由于龈沟液的流动，药物通常会被从牙周袋中冲洗掉。因此，给药技术的评估和局部药物释放装置的开发是牙周病研究的一个重要方面。本研究描述了一种新型的基于藻酸盐、可生物降解且易于应用的洗必泰（CHX）药物递送系统的开发与测试。制备了不同的微珠并载入CHX，通过高效液相色谱法（HPLC）研究其释放曲线。体外实验表明，基于藻酸盐的微珠中CHX的释放特性与临床认可的系统相当。然而，这种新型递送系统的许多特性表明其对牙周治疗具有优势。通过注射易于应用、生产成本低以及对患者相关具体情况的多功能适应性，可能会改善其在常规护理中的应用。
