Powers Deborah, Erickson Stephen, Swortwood Madeleine J
Department of Forensic Science, Sam Houston State University, Chemistry & Forensic Science Bldg, Rm 224, 1003 Bowers. Blvd, Box 2525, Huntsville, TX 77341.
Office of the Chief Medical Examiner, Arkansas State Crime Lab, 3 Natural Resources Dr., Little Rock, AR 72215.
J Forensic Sci. 2018 Jul;63(4):1229-1235. doi: 10.1111/1556-4029.13664. Epub 2017 Oct 3.
Recently, medical examiners reported two cases of a 21-year-old male and 24-year-old male with high amounts of morphine in their blood at autopsy. It was suspected that the decedents ingested lethal amounts of morphine from home-brewed poppy seed tea. No studies to date have investigated opium alkaloid content extracted from poppy seeds by home-brewing methods. Various poppy seed products were purchased from online sources and extracted with four home-brewing methods representative of recipes found on drug user forums. Morphine, codeine, and thebaine were quantified in the tea extracts by liquid chromatography-tandem mass spectrometry using a validated analytical method. Morphine, codeine, and thebaine concentrations from seeds were <1-2788 mg/kg, <1-247.6 mg/kg, and <1-124 mg/kg, respectively. Alkaloid yield varied between extractions, but regardless of extraction conditions, lethal amounts of morphine can be rinsed from poppy seed coats by home-brewing methods.
最近，法医报告了两例尸检时血液中含有大量吗啡的案例，死者分别为一名21岁男性和一名24岁男性。据推测，死者从自制的罂粟籽茶中摄入了致命剂量的吗啡。迄今为止，尚无研究调查通过家庭酿造方法从罂粟籽中提取的鸦片生物碱含量。从网上购买了各种罂粟籽产品，并采用四种家庭酿造方法进行提取，这些方法代表了吸毒者论坛上发现的配方。使用经过验证的分析方法，通过液相色谱 - 串联质谱法对茶提取物中的吗啡、可待因和蒂巴因进行定量。种子中吗啡、可待因和蒂巴因的浓度分别为<1 - 2788毫克/千克、<1 - 247.6毫克/千克和<1 - 124毫克/千克。不同提取物的生物碱产量有所不同，但无论提取条件如何，通过家庭酿造方法都可以从罂粟籽壳中冲洗出致命剂量的吗啡。
