Frix C D, Bronson D M, Rhee H L, Goldin H, Ringel E W
Department of Medicine, Cook County Hospital, Chicago, IL 60612.
J Am Acad Dermatol. 1988 May;18(5 Pt 2):1197-202. doi: 10.1016/s0190-9622(88)70124-3.
A 56-year-old black man developed a pemphigus foliaceus-like bullous eruption as the initial presentation of chronic T cell lymphocytic leukemia. Histologic examination disclosed superficial acantholysis consistent with pemphigus foliaceus and an infiltrate of atypical lymphoid cells in the papillary dermis. Repeated direct and indirect immunofluorescence studies yielded negative results. Acantholysis could be reproduced in vitro by incubation of normal human skin with the patient's serum and plasma but not with blister fluid. In the following months, the course of the bullous eruption paralleled that of the leukemia.
一名56岁的黑人男性出现类落叶型天疱疮大疱性皮疹，这是慢性T细胞淋巴细胞白血病的首发表现。组织学检查显示与落叶型天疱疮一致的表皮松解，以及乳头真皮层非典型淋巴细胞浸润。反复的直接和间接免疫荧光研究结果均为阴性。通过将正常人皮肤与患者的血清和血浆孵育，而非与疱液孵育，可在体外重现表皮松解。在接下来的几个月里，大疱性皮疹的病程与白血病的病程平行。
