Korea Food Research Institute, Seongnam-si, Gyeonggi-do 13539, Korea.
Molecules. 2017 Sep 30;22(10):1646. doi: 10.3390/molecules22101646.
Oxidative stress plays a significant role in the etiology of a variety of neurodegenerative diseases. In this study, we found that Melandrii Herba extract (ME) attenuated oxidative-induced damage in cells. Mechanistically, ME exhibited protection from H₂O₂-induced neurotoxicity via caspase-3 inactivation, Bcl-2 downregulation, Bax upregulation, and MAPK activation (ERK 1/2, JNK 1/2, and p38 MAPK) in vitro. Moreover, our in vivo data showed that ME was able to attenuate scopolamine-induced cognitive impairment. These results provide in vitro and in vivo evidence that ME exhibits neuroprotective properties against oxidative stress, which suggests that ME is worthy of further investigation as a complementary, or even as an alternative, product for preventing and treating neurodegenerative disorders.
氧化应激在多种神经退行性疾病的发病机制中起着重要作用。在本研究中，我们发现蔓荆子提取物（ME）可减轻细胞的氧化损伤。在机制上，ME 通过抑制 caspase-3 激活、下调 Bcl-2 和上调 Bax，以及激活 MAPK（ERK1/2、JNK1/2 和 p38MAPK），表现出对 H₂O₂诱导的神经毒性的保护作用。此外，我们的体内数据表明，ME 能够减轻东莨菪碱诱导的认知障碍。这些结果提供了体外和体内证据，表明 ME 对氧化应激具有神经保护作用，这表明 ME 值得进一步研究，作为预防和治疗神经退行性疾病的补充甚至替代产品。
