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麻醉诱导期间的低血压既不是可靠的,也不是比较麻醉师表现的有用的质量衡量标准。

Hypotension during induction of anaesthesia is neither a reliable nor a useful quality measure for comparison of anaesthetists' performance.

机构信息

Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA.

出版信息

Br J Anaesth. 2017 Jul 1;119(1):106-114. doi: 10.1093/bja/aex153.

Abstract

BACKGROUND

Identification of statistically reliable outcomes for comparison among anaesthetists is challenging. Time-weighted intraoperative mean arterial pressure <65 mm Hg (AUC 65 ) is associated with increased odds for myocardial damage. We explored retrospectively whether such hypotension before incision was statistically reliable for peer comparison.

METHODS

We retrieved electronic data between 2006 and 2015 at a tertiary care, academic hospital in the USA for patients at risk for myocardial damage (inpatient after surgery, ASA physical status ≥III, ≥50 yr of age, and case duration ≥60 min). We determined the percentage of anaesthetists comparable based on caseload and case-mix. The AUC 65 was compared amongst anaesthetists supervising ≥100 cases involving at-risk patients during the last 12 months.

RESULTS

Only 14.1% [95% confidence interval (CI) 13.6-14.5%] of cases involved patients who were 'at risk' during the 10 yr study period. A yearly average of 49 ( sd 6) anaesthetists supervised ≥100 cases of any type, of whom only 52% (95% CI 47.1-56.0%) supervised ≥100 cases involving at-risk patients. Thus, nearly half the anaesthetists would have been excluded from peer comparison. During the last 12 months, there were two outliers among 34 evaluable anaesthetists ( P <0.05, controlling for false discovery). However, their contribution to total hypotension amongst cases for all patients was small, because hypotension was widely distributed (e.g. 80% of hypotension attributable to 61.8% of anaesthetists, 95% CI 59.8-63.7%). There was no relationship between the AUC 65 and propofol induction dose.

CONCLUSIONS

The AUC 65 of time-weighted pre-incision hypotension is not a suitable metric for comparing anaesthetists. There were few at-risk patients, half the anaesthetists were not evaluable because of their case-mix and caseload, and hypotension was widely distributed.

摘要

背景

对于比较麻醉师的统计学可靠结果的识别具有挑战性。术中时间加权平均动脉压 <65mmHg(AUC65)与心肌损伤的几率增加相关。我们回顾性地探讨了切口前的这种低血压是否可用于统计学上可靠的同行比较。

方法

我们在美国一家三级保健、学术医院检索了 2006 年至 2015 年的电子数据,这些数据适用于存在心肌损伤风险的患者(术后住院患者、ASA 身体状况≥III 级、≥50 岁且手术持续时间≥60 分钟)。我们根据工作量和病例组合确定了基于可比麻醉师比例。比较了在过去 12 个月内监督≥100 例高危患者的麻醉师的 AUC65。

结果

在 10 年的研究期间,只有 14.1%(95%置信区间[CI]13.6-14.5%)的病例涉及有风险的患者。每年平均有 49(标准差 6)名麻醉师监督任何类型的≥100 例病例,其中只有 52%(95%CI47.1-56.0%)监督≥100 例涉及高危患者的病例。因此,近一半的麻醉师将被排除在同行比较之外。在过去的 12 个月中,在 34 名可评估麻醉师中,有 2 名异常值(P<0.05,控制假发现率)。然而,他们对所有患者病例中总低血压的贡献很小,因为低血压分布广泛(例如,80%的低血压归因于 61.8%的麻醉师,95%CI59.8-63.7%)。AUC65 与异丙酚诱导剂量之间没有关系。

结论

时间加权术前低血压的 AUC65 不是比较麻醉师的合适指标。高危患者很少,由于病例组合和工作量,一半的麻醉师无法评估,并且低血压分布广泛。

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