Boonpheng Boonphiphop, Cheungpasitporn Wisit, Wijarnpreecha Karn
Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Minerva Med. 2018 Apr;109(2):126-140. doi: 10.23736/S0026-4806.17.05403-9. Epub 2017 Oct 3.
Celiac disease, an inflammatory disease of small bowel caused by sensitivity to dietary gluten and related protein, affects approximately 0.5-1% of the population in the Western world. Extra-intestinal symptoms and associated diseases are increasingly recognized including diabetes mellitus type 1, thyroid disease, dermatitis herpetiformis and ataxia. There have also been a number of reports of various types of renal involvement in patients with celiac disease including diabetes nephropathy, IgA nephropathy, membranous nephropathy, membranoproliferative glomerulonephritis, nephrotic syndrome related to malabsorption, oxalate nephropathy, and associations of celiac disease with chronic kidney disease and end-stage kidney disease. This review aims to present the current literature on possible pathologic mechanisms underlying renal disease in patients with celiac disease.
乳糜泻是一种由对膳食麸质及相关蛋白质敏感引起的小肠炎症性疾病，在西方世界约影响0.5%-1%的人口。肠外症状和相关疾病越来越受到认可，包括1型糖尿病、甲状腺疾病、疱疹样皮炎和共济失调。也有许多关于乳糜泻患者出现各种肾脏受累情况的报道，包括糖尿病肾病、IgA肾病、膜性肾病、膜增生性肾小球肾炎、与吸收不良相关的肾病综合征、草酸盐肾病，以及乳糜泻与慢性肾脏病和终末期肾病的关联。本综述旨在介绍目前关于乳糜泻患者肾脏疾病潜在病理机制的文献。
