Ohta H, Endo K, Fujita T, Koizumi M, Konishi J, Maki A, Mori K, Ozawa K, Inoue G, Nakano Y
Department of Nuclear Medicine and Surgery, Kyoto University School of Medicine, Japan.
J Nucl Med. 1988 Jun;29(6):1130-5.
This case report describes the localization and categorization of tumors using 99mTc(V)-dimercaptosuccinic acid and [131I]metaiodobenzylguanidine scans in a very uncommon case of medullary thyroid carcinoma associated with pheochromocytoma (Sipple's syndrome) and hepatocellular carcinoma. Technetium-99m(V)-dimercaptosuccinic acid showed accumulation only in medullary thyroid carcinoma, but [131I]metaiodobenzylguanidine scans were positive in both medullary thyroid carcinoma and pheochromocytoma. In advanced Sipple's syndrome, combined use of [99mTc(V)]dimercaptosuccinic acid and [131I]metaiodobenzylguanidine may be useful for the categorization of tumor mass lesions and planning appropriate therapy.
本病例报告描述了在一例非常罕见的伴有嗜铬细胞瘤（西普尔综合征）和肝细胞癌的甲状腺髓样癌病例中，使用99mTc(V)-二巯基丁二酸和[131I]间碘苄胍扫描对肿瘤进行定位和分类的情况。锝-99m(V)-二巯基丁二酸仅在甲状腺髓样癌中显示有聚集，但[131I]间碘苄胍扫描在甲状腺髓样癌和嗜铬细胞瘤中均为阳性。在晚期西普尔综合征中，联合使用[99mTc(V)]二巯基丁二酸和[131I]间碘苄胍可能有助于对肿瘤肿块病变进行分类并规划适当的治疗方案。
