Itoh H, Sugie K, Toyooka S, Kawase M, Mukaino S, Hazama F, Endo K, Torizuka K, Nakao K, Imura H
Eur J Nucl Med. 1986;11(12):502-4. doi: 10.1007/BF00252798.
While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.
虽然¹³¹I-间碘苄胍（¹³¹I-MIBG）扫描已使嗜铬细胞瘤和神经母细胞瘤的闪烁显像成为可能，但最近有报道称该药物在甲状腺髓样癌中也有蓄积。我们报告了1例患有Sipple综合征（IIa型多发性内分泌腺瘤病）的患者，通过¹³¹I-MIBG扫描，我们能够识别出甲状腺髓样癌的远处转移和局部侵犯，以及原发性甲状腺肿瘤和右肾上腺嗜铬细胞瘤。该病例突出了¹³¹I-MIBG在检测转移性甲状腺髓样癌中的作用，并表明该药物在肿瘤治疗中也可能具有治疗用途。
