大麻其他成分对四氢大麻酚致僵效应的抑制作用
Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.
作者信息
Formukong E A, Evans A T, Evans F J
机构信息
Department of Pharmacognosy, School of Pharmacy, University of London, UK.
出版信息
J Pharm Pharmacol. 1988 Feb;40(2):132-4. doi: 10.1111/j.2042-7158.1988.tb05198.x.
Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.
四氢大麻酚（THC）可诱发小鼠僵住症，而一种大麻油（THC含量为6.68% w/w）、四种大麻素及一种合成混合物则不会。大麻酚（CBN）和蛇麻脂醇在早晨和傍晚可抑制THC诱发的僵住症，但大麻二酚（CBD）仅在傍晚有此作用。CBN与CBD的组合在早晨对THC诱发僵住症的抑制作用与单独使用CBN时相当，但在傍晚这种抑制作用比单独使用CBN时更强。
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