Rai Nitish, Kothari Shyam S
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
BMJ Case Rep. 2017 Oct 3;2017:bcr-2017-221313. doi: 10.1136/bcr-2017-221313.
Prosthetic heart valve thrombosis (PHVT) is a major cause of morbidity and mortality in patients with mechanical heart valves. We present a case of recurrent PHVT associated with eosinophilia. A 17-year-old girl underwent aortic and mitral valve replacement for rheumatic heart disease. Over a period of 4 years, she had four episodes of PHVT despite oral anticoagulation with adequate INR. Her investigations revealed eosinophilia which was missed during the previous episodes. No further episodes of PHVT occurred after treatment of eosinophilia with steroids on limited follow-up.
人工心脏瓣膜血栓形成（PHVT）是机械心脏瓣膜患者发病和死亡的主要原因。我们报告一例与嗜酸性粒细胞增多相关的复发性PHVT病例。一名17岁女孩因风湿性心脏病接受了主动脉瓣和二尖瓣置换术。在4年的时间里，尽管口服抗凝剂且国际标准化比值（INR）合适，她仍发生了4次PHVT发作。她的检查发现有嗜酸性粒细胞增多，这在前几次发作中被漏诊。在有限的随访期间，用类固醇治疗嗜酸性粒细胞增多后未再发生PHVT发作。
